What are peptides?

In their purest form, peptides are two or more amino acids – the building blocks of proteins – joined together. They range from very simple to very complex. A peptide can also be considered a hormone, such as in the case of human growth hormone. hGH is an example of a complex polypeptide composed of 191 amino acids. It is produced within the body and controls a vast array of biological processes, including stimulation of cell growth, cell regeneration, and cell reproduction. 

Peptides are typically administered six nights weekly at bedtime, either by subcutaneous injection or sublingually via a small troche dissolved under the tongue.

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Sermorelin, a synthetic polypeptide composed of the first 1-29 amino acids of the human growth hormone chain, is an analog of growth hormone-releasing hormone (GHRH). Sermorelin stimulates the natural pulse of growth hormone released by the body each night while sleeping. Sermorelin has an approximate half-life of ten minutes.


CJC-1295, also known as modified growth hormone-releasing hormone, CJC-1295 is similar to sermorelin in functionality and structure. It is a 29-amino-acid-long polypeptide that induces production and release of hGH. Its main difference from sermorelin is that some of the amino acids have been replaced to extend the biological half-life to over thirty minutes.


Ipamorelin is a pentapeptide composed of five amino acids and induces the secretion of hGH. It has been shown in multiple studies to increase plasma levels of growth hormone significantly.  Ipamorelin combined with Sermorelin or CJC-1295 due to the synergistic effect of increased hGH levels.

What to expect from use of peptides

The use of peptides to increase growth hormone production and release takes time. Patients may notice improved sleep quality within the first two weeks of treatment, but changes in body composition can take up to three months. Some reported benefits include:

  • Increased lean muscle mass
  • Decreased visceral fat
  • Improved energy
  • Improvement in muscle recovery time
  • Improved sleep
  • Improved libido
  • Improved skin elasticity

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